Are Polynucleotides Safe? And Are They Right for Me?

Your July Treatment of the Month at Skin & Sanctuary (which means a complimentary consultation and £50 off if booked in July).

There’s a quiet revolution happening in aesthetics - one that doesn’t freeze, plump, or over-correct. It regenerates.

And at Skin & Sanctuary, that’s exactly why Polynucleotides are our Treatment of the Month.

But with any new injectable, the first question many of our clients ask is:

Is it safe?

The second: Will it actually do anything?

Let’s answer both - with care, clarity, and what we’ve seen in clinic.

What Are Polynucleotides - Really?

Forget the clickbait. Polynucleotides are not fish DNA, and they’re certainly not “salmon sperm.” (We’re still unsure who coined that phrase - but it’s not doing anyone any favours.)

Polynucleotides are purified, biocompatible molecules derived from DNA fragments. When injected into the skin, they:

➤ Stimulate cell repair and collagen production
➤ Calm inflammation
➤ Hydrate from within
➤ Strengthen the skin barrier
➤ Improve elasticity and overall texture

They don’t freeze your muscles. They don’t add volume.
They support your skin to heal, hydrate, and renew itself.

Are They Safe?

Yes - and not just in theory.

Polynucleotides have been used in medicine for decades, particularly in wound healing and eye surgery. Their safety profile is excellent, with minimal risk of allergic reaction or long-term complications. At Skin & Sanctuary, we use premium formulations (like Polyphil from Croma) because we trust their science, sourcing, and results.

As always, we only recommend treatments that we’re confident are:

➤  Clinically backed
➤  Ethically formulated
➤  Safe across diverse skin types and tones

And we’ll never offer a treatment unless we believe it genuinely belongs in your plan—not just on our menu.

Who Are Polynucleotides Right For?

If your skin is feeling tired, fragile, or just not quite itself - Polynucleotides could be exactly what you need.

They’re ideal for:

➤ Skin that’s inflamed, sensitised, or recovering from damage
➤ Fine lines and loss of elasticity (without volume loss)
➤ Clients post-baby, post-burnout, post-stress
➤ Perimenopausal and menopausal skin
➤ Anyone seeking natural, regenerative change 

They also pair beautifully with other treatments like microneedling, RF, and LED, especially if you’re building long-term skin resilience.

And yes, they’re safe during summer, and with careful planning, they can be an excellent first injectable if you’ve never tried one before.

Let’s Make It Personal

No two faces - or journeys - are the same.

That’s why every Polynucleotide plan at Skin & Sanctuary starts with a consultation. We’ll look at your skin, listen to your goals, and build something tailored. Not templated.

And because this is our Treatment of the Month, we’re prioritising appointments with our team for those curious to try.

Also, as Treatment of the Month, not only are all consultations complimentary but should you decide to go ahead, £50 will be taken off the cost. 

Still Unsure? That’s Okay.

This isn’t about jumping on a trend. It’s about understanding what your skin really needs - and treating it with the same intelligence and integrity that you treat the rest of your health.

This is about your skin, your health - we are here to provide a level of expertise and clarity that helps you understand the options

If you’re curious, book a consultation. If you’re ready, we’d love to begin your journey.

Because subtle doesn’t mean ineffective. It means intelligent.

Live beautifully.